Studies
Scientific References
At RegenaPept, we believe transparency starts with the science. BPC-157 is not a trend — it is a compound that has been studied for decades in the field of peptides.
This page brings together selected peer-reviewed research exploring the biological mechanisms and potential applications of BPC-157 across different systems.
The studies below are provided to help you better understand why BPC-157 continues to attract scientific interest and how it differs from conventional recovery approaches.
Our goal is simple: to give you clear access to the research so you can make informed decisions based on evidence, not hype.
Muscle & Tissue Repair
BPC-157 accelerates healing by activating the VEGFR2 signaling pathway and promoting angiogenesis (the formation of new blood vessels), ensuring a steady supply of oxygen and nutrients to damaged tissues.
Accelerated Wound Healing: Analysis of reparative properties in skin lesions.
Burn Recovery: Study on tissue restructuring and re-epithelialization.
Muscle Crushes & Strains: Effective restoration of muscle function and reduction of fibrosis after trauma.
Muscle-to-Bone Reattachment: Novel research on the restoration of severed junctions.
Tendons, Ligaments & Joints
Tendons are notoriously slow to heal due to poor blood supply. BPC-157 increases Growth Hormone Receptor (GHR) expression in fibroblasts, making these tissues significantly more responsive to the body's natural healing signals.
Achilles Regeneration: Improvements in biomechanical stability and fiber alignment.
Fibroblast Migration: Mechanisms of how BPC-157 directs repair cells.
Chronic Knee Pain (Human Study): A retrospective analysis showing that 91.6% of patients reported significant relief and improved mobility.
Gastrointestinal Health (Gut Repair)
As a peptide naturally found in human gastric juice, BPC-157 protects the mucosal lining and strengthens the intestinal barrier (Leaky Gut) by stabilizing "tight junctions" between cells.
Ulcerative Colitis Therapy: Clinical Phase II trial results on efficacy in Inflammatory Bowel Disease (IBD).
Fistula Healing: Successful closure of complex gastrointestinal and colocutaneous defects.
NSAID-Induced Damage Protection: Neutralizing the damaging effects of common painkillers (Ibuprofen, Aspirin) on the gut and liver.
Oral Health & Periodontitis: Protection of gum tissue and alveolar bone.
Neurology & The Gut-Brain Axis
BPC-157 acts as a bridge in the gut-brain axis, interacting with neurotransmitters like GABA and Dopamine to support nerve regeneration and emotional well-being.
Peripheral Nerve Regeneration: Restoring function after traumatic nerve transection (e.g., sciatic nerve).
CNS Neuroprotection: Reducing damage from traumatic brain injuries (TBI) and strokes.
GABAergic Modulation: Supporting the body’s response to stress and improving sleep architecture through increased GABA tone.
The Arginine Salt Advantage
The Arginine Salt (Bepecin) was specifically engineered to overcome the instability of standard peptides, making it the only reliable choice for oral supplementation.
Thermodynamic Stability: Proof of shelf-life at room temperature and resistance to gastric acid.
Comparative Bioavailability: Why salt-form choice determines the success of oral delivery.